Zhenghuai Tan Selected Research

Mannich Bases

1/2021	Novel 3-benzylidene/benzylphthalide Mannich base derivatives as potential multifunctional agents for the treatment of Alzheimer's disease.
1/2019	Discovery of 4'-OH-flurbiprofen Mannich base derivatives as potential Alzheimer's disease treatment with multiple inhibitory activities.
1/2017	Aurone Mannich base derivatives as promising multifunctional agents with acetylcholinesterase inhibition, anti-β-amyloid aggragation and neuroprotective properties for the treatment of Alzheimer's disease.
1/2017	Pyridoxine-resveratrol hybrids Mannich base derivatives as novel dual inhibitors of AChE and MAO-B with antioxidant and metal-chelating properties for the treatment of Alzheimer's disease.

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Zhenghuai Tan Research Topics

Disease

31	Alzheimer Disease (Alzheimer's Disease) 12/2023 - 04/2014
6	Memory Disorders (Memory Loss) 01/2020 - 04/2014
5	Cognitive Dysfunction 12/2023 - 02/2015
2	Neuroinflammatory Diseases 03/2023 - 02/2022
1	Acute Lung Injury 12/2022
1	Inflammation (Inflammations) 10/2022
1	Parkinson Disease (Parkinson's Disease) 01/2022
1	Dementia (Dementias) 01/2022
1	Fatty Liver 08/2020
1	Necrosis 08/2020
1	Tuberculosis (Tuberculoses) 08/2020
1	Vascular System Injuries 01/2019
1	Dyskinesias (Dyskinesia) 01/2019
1	Atherosclerosis 10/2011
1	Diabetes Complications 07/2008
1	Diabetic Nephropathies (Diabetic Nephropathy) 07/2008

Drug/Important Bio-Agent (IBA)

11	Scopolamine (Hyoscine)FDA Link 12/2023 - 04/2014
10	LigandsIBA 02/2022 - 02/2015
5	AntioxidantsIBA 02/2022 - 02/2015
4	scutellareinIBA 12/2023 - 02/2015
4	Mannich BasesIBA 01/2021 - 01/2017
4	Amyloid (Amyloid Fibrils)IBA 01/2018 - 04/2016
3	Rivastigmine (Exelon)FDA LinkGeneric 12/2023 - 02/2015
3	Chalcone (Benzalacetophenone)IBA 04/2021 - 09/2019
3	AcetylcholinesteraseIBA 01/2018 - 01/2017
2	MetalsIBA 03/2023 - 01/2017
2	Cholinergic Agents (Cholinergics)IBA 02/2022 - 02/2015
2	Monoamine Oxidase (MAO)IBA 01/2022 - 01/2017
2	GenisteinIBA 01/2021 - 04/2014
2	Flurbiprofen (Froben)FDA LinkGeneric 01/2020 - 01/2019
2	CarbamatesIBA 09/2019 - 02/2015
2	Neuroprotective AgentsIBA 01/2019 - 02/2015
2	ferulic acid (sodium ferulate)IBA 01/2019 - 04/2017
2	Oxidoreductases (Dehydrogenase)IBA 01/2018 - 01/2017
2	pterostilbeneIBA 01/2018 - 04/2016
2	auroneIBA 01/2017 - 01/2016
1	3-n-butylphthalide (butylphthalide)IBA 12/2023
1	Salicylic Acid (2 Hydroxybenzoic Acid)FDA LinkGeneric 12/2023
1	Donepezil (Aricept)FDA LinkGeneric 12/2023
1	naringeninIBA 12/2022
1	Volatile Oils (Essential Oils)IBA 12/2022
1	Interleukin-6 (Interleukin 6)IBA 10/2022
1	6- hydroxy- 2,5,7,8- tetramethylchroman- 2- carboxylic acid (Trolox)IBA 02/2022
1	Chelating AgentsIBA 02/2022
1	cinnamic acidIBA 01/2021
1	Messenger RNA (mRNA)IBA 08/2020
1	Transaminases (Aminotransferases)IBA 08/2020
1	CholesterolIBA 08/2020
1	Lipoprotein Lipase (Diacylglycerol Lipase)IBA 08/2020
1	Proteins (Proteins, Gene)FDA Link 08/2020
1	Pyrazinamide FDA LinkGeneric 08/2020
1	Rifampin (Rifampicin)FDA LinkGeneric 08/2020
1	Sterol Regulatory Element Binding Protein 1IBA 08/2020
1	ApigeninIBA 02/2020
1	Cholinesterase Inhibitors (Anticholinesterases)IBA 01/2020
1	AminesIBA 01/2020
1	phthalideIBA 01/2020
1	Clioquinol (Vioform)FDA Link 01/2020
1	salicylamideIBA 01/2019
1	thioxanthoneIBA 01/2017
1	Pyridoxine (Pyridoxin)FDA LinkGeneric 01/2017
1	ResveratrolIBA 01/2017
1	Cholinesterases (Cholinesterase)IBA 04/2016
1	Trace Elements (Biometals)IBA 02/2015
1	scutellarinIBA 02/2015
1	CarbonIBA 04/2014
1	SaponinsIBA 10/2011
1	ZymosanIBA 10/2011
1	IntegrinsIBA 10/2011
1	salvianolic acid BIBA 07/2008
1	NF-kappa B (NF-kB)IBA 07/2008
1	Glucose (Dextrose)FDA LinkGeneric 07/2008

Therapy/Procedure

1	Chinese Traditional Medicine (Traditional Chinese Medicine) 01/2022
1	Therapeutics 01/2020